Symbol
Name
ID

Sgpl1
sphingosine phosphate lyase 1
MGI:1261415

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Lymphopenia
Disease(s) Associated with SGPL1	Lymphopenia
nephrotic syndrome type 14

Mouse Phenotypes

abnormal leukocyte migration

thymus cortex hypoplasia

thymus medulla hyperplasia

thymus hypoplasia

increased thymocyte number

abnormal lymphopoiesis

decreased double-positive T cell number

decreased neutrophil cell number

increased granulocyte number

decreased follicular B cell number

decreased marginal zone B cell number

decreased B cell number

decreased pre-B cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

abnormal regulatory T cell number

decreased T cell number

decreased single-positive T cell number

decreased lymphocyte cell number

increased osteoclast cell number

increased monocyte cell number

abnormal osteoclast morphology

spleen hypoplasia

abnormal spleen periarteriolar lymphoid sheath morphology

abnormal T cell physiology

abnormal lymph node morphology

lymph node hypoplasia

lymphoid hypoplasia

abnormal immune system physiology

abnormal type IV hypersensitivity reaction

decreased susceptibility to experimental autoimmune encephalomyelitis

kidney inflammation

Availability

Mouse Genotype

Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}

Sgpl1^{Gt(ROSA)78Sor}/Sgpl1^{Gt(ROSA)78Sor}

Sgpl1^tm1.2Npa/Sgpl1^tm1.2Npa

Actb^{tm4(cre/ERT2)Npa}/Actb⁺
Sgpl1^tm1.1Npa/Sgpl1^tm1.1Npa (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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